Process Scale-up Study of a Raticide Brodifacoum

王建中; 张丽萍

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Process Scale-up Study of a Raticide Brodifacoum

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- Process Scale-up Study of a Raticide Brodifacoum
- 杀鼠剂原药——大隆合成的放大研究
- Issue 2, Pages: 175-177(2000)
- 作者机构：
  
  华北工学院化学工程系
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2000
- 稿件说明：
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王建中, 张丽萍. Process Scale-up Study of a Raticide Brodifacoum[J]. 2000, (2): 175-177.
DOI：

王建中, 张丽萍. Process Scale-up Study of a Raticide Brodifacoum[J]. 2000, (2): 175-177. DOI：

摘要

目的　在实验室进行大隆合成的放大研究

以便于技术的推广和应用 .方法　以苯乙酰氯和对溴联苯、 4 -羟基香豆素等为原料进行大隆的公斤级放大实验 .结果　根据实验给出了各步工艺条件

操作方法

生产工艺流程示意图

投资设备一览表

各步产品收率及产品质量指标 .结论　大隆的总收率为 3 .4 %

产品的含量≥ 95%

薄层分析 :在 Rf为 0 .3和 0 .4处有两个同分异构吸收谱

Abstract

Aim Process amplification study was carried out in the laboratory to promote the spread and application of the technology. Methods One kilogram scale amplification experiment was performed by using phenylacetyl chloride

para bromobiphenyl and 4 hydroxycoumarin as the raw materials. Results The process conditions

operation methods

technological flow chart

equipment list

product yields and product quality index are given on the basis of experiments. Conclusion Yield of brodifacoum is 3.4%

product content≥95% and thin layer chromatography shows two isomeric absorption bands at R f=0.3 and 0.4.

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Keywords

references

[1 ]　王建中 ,张丽萍 .杀鼠剂大隆的合成 [J].精细化工 ,1 996,1 3 ( 6) :1 8～ 2 1 .

[2 ]　王建中 ,黄继祖 ,张丽萍 .3 -(对溴联苯 ) -1 ,2 ,3 ,4 -四氢 -1 -萘醇的合成 [J].华北工学院学报 ,1 997,1 9( 2 ) :1 67～ 1 70 .

[3 ]　王葆仁 .有机合成反应 [M].北京 :科学出版社 ,1 985.64 6.

[4 ]　 Roys S.Synthesis of some tetrahydronaphthyl and flaranyl-coumarins[J].JChem Soc Perkin Trans,1 976,1 1 ( 1 ) :1 1 90 .

　 Yuen S H.Determination of the Rodenticides Difenacoum and Brodifacoum in Finished Baits by Reversed-phaseLiquid Chromatography[M].Analyst,August.1 987.1 0 3 .84 2～ 850 .

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