Aim Process amplification study was carried out in the laboratory to promote the spread and application of the technology. Methods One kilogram scale amplification experiment was performed by using phenylacetyl chloride

para bromobiphenyl and 4 hydroxycoumarin as the raw materials. Results The process conditions

operation methods

technological flow chart

equipment list

product yields and product quality index are given on the basis of experiments. Conclusion Yield of brodifacoum is 3.4%

product content≥95% and thin layer chromatography shows two isomeric absorption bands at R f=0.3 and 0.4.